Ground Controls->Non_PDF->Print->Spreads
Yes - This Ground Control will trigger if Spreads are set to on when the document is printed. This can cause jobs to be cutoff on the actual film or plate output.
No - This Ground Control will trigger if Spreads are set to off when the document is printed. This is typically what you want, but most people leave this Ground Control Off by default as they only want to be warned if spreads have been turned on.